An evaluation of the main nanotechnology approaches to improve the therapeutic potential of polyphenols against cancer Nutrients_MDPI unicampoficial polyphenol cancer anticancer nontechnology nanotech therepeutic
By Neha MathurJul 18 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Nutrients Journal, researchers comprehensively evaluated all nanotechnology-based approaches used to improve the therapeutic effectiveness of polyphenols against cancer.
Polyphenols are bioactive agents present in many plants, fruits, and vegetables. Studies have highlighted that some polyphenols, such as curcumin, epigallocatechin-3-gallate , quercetin, and resveratrol, have antiproliferative activity, essential to fight cancerous cells. Regardless of type, all these materials confer protection to polyphenols against the hostile environment of the human digestive system, thus, facilitating a controlled and targeted delivery to the target tissue of a cancer patient.
EGCG, found in green tea , suppressed the proliferation of H1299 lung cancer cells in concentrations >20 μM in a study by Chen et al. . Its LEGCG derivate showed cell apoptosis rates of 8.63%, 12.78%, 25.62%, and 58.51% at concentrations zero, 10, 20, and 40 μg/mL, respectively. Recently, Hashemzaei et al. evaluated the effect of quercetin in preclinical studies in mice. The treatment comprised 50, 100, and 200 mg/kg concentrations of quercetin and 5% dextrose for the control group. After 18 days, this treatment shrunk breast tumor sizes and improved survival rates in the group treated with a 200 mg/kg dosage.
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