More than 40 genes linked for the first time to Alzheimer's disease in a 'landmark' study.
Alzheimer's disease is the most common cause of dementia and affects 850,000 people in the UK, identified 75 genes associated with an increased risk of developing Alzheimer's disease, including 42 genes not previously implicated in the condition.
A group of 111,326 people with Alzheimer's disease were compared with 677,663 healthy individuals to look for differences in their genetic make-up. "The results support our growing knowledge that Alzheimer's disease is an extremely complex condition, with multiple triggers, biological pathways and cell types involved in its development."Diet, exercise and smoking influence development of Alzheimer's but it's mostly genetics, according to Prof WilliamsShe added: "Components of our immune system have a big role to play in the development of the disease.
"However, 60-80% of disease risk is based on our genetics and therefore we must continue to seek out the biological causes and develop much-needed treatments for the millions of people affected worldwide."
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