The gut microbiota of individuals with pre-symptomatic Alzheimer’s differs from those of healthy people. Individuals in the initial phase of Alzheimer's disease, where brain alterations have started but before cognitive symptoms become apparent, have a distinct mix of gut bacteria compared to healt
Researchers at Washington University in St. Louis found that individuals in the earliest stages of Alzheimer’s have distinct gut bacteria compared to healthy peers, suggesting the gut microbiome might help predict or treat dementia. The study, conducted on cognitively normal participants, highlighted the gut-brain link, but it remains unclear if gut changes cause brain changes or vice versa.
The idea of studying the connection between the gut microbiome and Alzheimer’s disease came together at a youth soccer game, where Dantas and Beau M. Ances, MD, Ph.D., the Daniel J. Brennan Professor of Neurology, chatted while their children played. Ances treats and studies people with Alzheimer’s disease; Dantas is an expert on the gut microbiome.
During the early stage of Alzheimer’s disease, which can last two decades or more, affected people accumulate clumps of the proteins amyloid beta and tau in their brains, but do not exhibit signs of neurodegeneration or cognitive decline. An analysis revealed that healthy people and people with preclinical Alzheimer’s disease have markedly different gut bacteria — in terms of theof bacteria present and the biological processes in which those bacteria are involved — despite eating basically the same diet. These differences correlated with amyloid and tau levels, which rise before cognitive symptoms appear, but did not correlate with neurodegeneration, which becomes evident about the time cognitive skills start to decline.
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