Accidental Innovation: Notre Dame’s Unexpected Discovery Enhances Drug Potency — Researchers at the Univers |
A newly discovered technique, reported in the journal“If you take sand and heat it to 500 degrees, nothing changes,” said Bradley Smith, the Emil T. Hofman Professor of Science at the University of Notre Dame.
To confirm that the dye had fully infused, Shaffer and Zhai enlisted the help of Tatyana Orlova and Maksym Zhukovskyi, microscopy experts at the Notre Dame Integrated Imaging Facility.Orlova and Zhukovskyi produced high-resolution electron microscopy images that showed that not only had the dye infused, the silica particles themselves had changed shape. The original particles were solitary spheres lightly dotted with pores like the skin of an orange.
Smith and his students have found that subtle changes in the loading procedure allow them to vary the thickness of the particles, offering a whole host of new options to fine-tune the particles to release drugs at different rates. The new particle’s unique structure may also make it possible to load it with more than one ingredient — for example, a drug in the outer layer and a dye inside the “raspberry” — to enhance researchers’ ability to observe the way drugs release.
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