Abnormally low autoantibody activity significantly associated with autism severity institutpasteur UBO_UnivBrest autoantibody antibody autism
By Dr. Priyom Bose, Ph.D.Mar 13 2023Reviewed by Benedette Cuffari, M.Sc. Autism spectrum disorder is a neurodevelopmental condition that causes repetitive behaviors and social communication impairments in children. Scientists are actively studying various aspects of immune dysfunctions related to ASD to better understand their role in the neurodevelopment of children with ASD.
Background ASD is associated with several immunological defects, such as reduced complement proteins, increased number and altered functions of natural killer cells and T-cells, gastrointestinal tract inflammation, and uncharacteristic proliferative responses to mitogens. In addition, children with ASD often exhibit abnormal B-cell and monocyte levels.
Recently, scientists have reported on autoimmune processes associated with the central nervous system that cause mental disorders. For example, there have been several reports of children diagnosed with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. Similar conditions have been found in children with autism as well.
About the study Natural anti-F2 autoantibodies help recognize the immune self. The current study investigated the role of NAAbs, including the natural anti-F2 autoantibodies, in changing self-recognition mechanisms in autism. Study findings The serum levels of IgG anti-F2 autoantibodies were significantly lower in children with autism as compared to the TD group and were negatively associated with autism severity. In addition, IQ scores were significantly and negatively correlated with IgG anti-F2 levels in the autism group. Thus, autoantibody levels were more specific to autism than to intellectual disability.
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