A recent technical report in Nature Cell Biology has introduced a novel method to examine specific alterations in DNA following replication. Scientists have devised a highly sensitive, quantitative method utilizing mass spectrometry known as iDEMS (isolation of DNA by EdU labeling for Mass Spectrome
The new approach is called iDEMS .has introduced a novel method to examine specific alterations infollowing replication. Scientists have devised a highly sensitive, quantitative method utilizing mass spectrometry known as iDEMS .
When DNA is replicated during cell division, the epigenetic marks associated with the DNA, including DNA methylation, are diluted. The newly created DNA strands need to re-establish the level and pattern of methylation to maintain control of gene expression, genomic stability, and the epigenetic memory of the cell’s identity.
“Over time cells don’t have long enough to re-establish their methylation after replication, and the methylation of the genome is eventually diluted. This is the first time very clear kinetics for methylation re-establishment have been shown. Furthermore, we saw absolute quantification of the levels of DNA methylation, enabling us to distinguish which methylation marks were newly established. This gave us confidence in our kinetic measurements,” Dr. Stewart-Morgan reports.
Looking to the future, iDEMS will be useful in profiling methylation and hydroxymethylation dynamics in different cellular contexts, including aging and cancer evolution. Compared with sequencing data, mass spectrometry provides a simple, fast readout, and iDEMS could therefore be useful where efficiency is key, such as in medical settings and drug discovery studies.
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