A Remedy developer is modding Control on PC with a range of excellent visual upgrades. Here's digitalfoundry with the story:
Remedy's Control has always been a special game for Digital Foundry. Originally released in 2019, the PC version in particular wowed us with its slick destruction physics and groundbreaking ray tracing implementation.
Here's our full HDR video for Filippo Tarpini's Control upgrade. It may not be an official patch, but it's too good not to try - and Filippo himself does work for Remedy... Another advantage from the new patch is how texture loading is done via a higher texture streaming quality setting. Even on ultra in the old game, just running through the world could cause textures to load in late, visibly flipping in quality. With the new max texture streaming quality option, this behaviour appears to be nearly completely eliminated. Once again just another smaller tweak to make the game scale much higher for current gen GPUs.
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Vitamin D deficiency in pregnancy and the risk of preterm birth: a nested case–control study - BMC Pregnancy and ChildbirthBackground Each year, an estimated 15 million babies are born preterm. Micronutrient deficiencies, including vitamin D deficiency (VDD), are common in many low- and middle-income countries (LMICs), and these conditions are often associated with adverse pregnancy outcomes. Bangladesh experiences a high prevalence of VDD. The country also has a high preterm birth (PTB) rate. Using data from a population-based pregnancy cohort, we estimated the burden of VDD during pregnancy and its association with PTB. Methods Pregnant women (N = 3,000) were enrolled after ultrasound confirmation of gestational age at 8–19 weeks of gestation. Trained health workers prospectively collected phenotypic and epidemiological data at scheduled home visits. Trained phlebotomists collected maternal blood samples at enrollment and 24 -28 weeks of gestation. Aliquots of serum were stored at -800 C. We conducted a nested case–control study with all PTB (n = 262) and a random sample of term births (n = 668). The outcome, PTB, was defined as live births 30.25 nmol/L). We used logistic regression to determine the association of VDD with PTB, adjusting for potential confounders. Results The median and interquartile range of serum 25(OH)D was 38.0 nmol/L; 30.18 to 48.52 (nmol/L). After adjusting for co-variates, VDD was significantly associated with PTB [adjusted odds ratio (aOR) = 1.53, 95% confidence interval (CI) = 1.10 – 2.12]. The risk of PTB was also higher among women who were shorter (aOR = 1.81, 95% CI: 1.27–2.57), primiparous (aOR = 1.55, 95% CI = 1.12 – 2.12), passive smokers (aOR = 1.60, 95% CI = 1.09 – 2.34), and those who received iron supplementation during pregnancy (aOR = 1.66, 95% CI: 1.17, 2.37). Conclusion VDD is common in Bangladeshi pregnant women and is associated with an increased risk of PTB.
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