The researchers found that vitronectin is a promising target for macular degeneration. Francesca Marassi, Ph.D., a professor at Sanford Burnham Prebys, is leading research that is shedding light on the molecular mechanisms behind macular degeneration, which accounts for over 90% of all age-related
The researchers found that vitronectin is a promising target for macular degeneration., is leading research that is shedding light on the molecular mechanisms behind macular degeneration, which accounts for over 90% of all age-related vision loss.
“This protein is an important target for macular degeneration because it accumulates in the back of the eye, causing vision loss. Similar deposits appear in the brain in Alzheimer’s disease and in the arteries in atherosclerosis,” says Marassi. “We want to understand why this happens and leverage this knowledge to develop new treatments.”
Through detailed biochemical analysis, the researchers found that the protein can subtly change its shape under pressure. These changes cause it to bond more easily to calcium ions in the blood, which the researchers suggest leads to the buildup of calcified plaque deposits characteristic of macular degeneration and other age-related diseases.
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