A “grand unifying theory” of brain ageing suggests malfunctioning mitochondria might be to blame for Alzheimer’s and other brain conditions. And this new avenue of exploration already has some potential therapies at the ready
HAS the cause of brain degeneration been hiding in plain sight? More than 40 years ago, scientists noticed differences in the mitochondria of people with. These cellular power stations, which pump out the energy necessary for normal cognitive function, were less abundant in the brains of people with Alzheimer’s, and those mitochondria that remained appeared to be misshapen.
Despite these intriguing findings, scientists remained focused on the now infamous amyloid theory of Alzheimer’s, in which cellular debris called plaques and tangles were thought to underlie the condition. However,
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