A new class of antibiotics delivers promising trial results against tuberculosis. Read the latest in The Clinical Pipeline, from CyrilPedia
on 14 November 2022 the positive results of its open-label phase 2a trial of GSK30336656, a first-in-class drug for the treatment of tuberculosis. The molecule functions as an inhibitor of theenzyme leucyl-tRNA synthetase, blocking protein synthesis.
Patients with drug-susceptible pulmonary tuberculosis treated with the investigational drug for 14 days showed a significant, dose-dependent reduction in colony-forming units in their sputum, the trial’s primary endpoint. Andreas Diacon, GSK’s Chief Scientific Officer, stated in the press release that “GSK3036656 is a potential new antibiotic for tuberculosis that can be used in low, once-daily doses.
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