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. The team took a molecular red pen to donor pigs’ genomes, editing the animals’ organs to be more of a match for humans. Such an editing strategy could one day make it more likely for people’s bodies to accept organs from different species.
That’s where cross-species transplantation — giving people organs from other animals — comes in, Curtis said. It’s “the only near-term viable solution to solving this huge shortfall in organ availability.” The edits, which strip away some pig aspects and add in human ones, fall into three main categories designed to make the animals’ organs safer for human use. They lop off stranger-danger sugars from pigs’ cells, insert human genes to help prevent organ rejection and knock out potentially harmful retroviruses embedded in the pigs’ genomes. “This is probably the most genetically modified pig that I’ve seen described in the literature,” Locke says.
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